Chana Nachenberg, of American-Israeli descent, was 31 years old at the time of the deadly attack on the pizzeria.
An American-Israeli woman has died after 22 years in a coma from injuries sustained in a Palestinian suicide attack in Jerusalem.
Chana Nachenberg was 31 years old at the time of the attack on the Sbarro pizzeria. 15 people were killed in the attack, including a pregnant woman and seven children.
She is the third citizen of the United States of America (USA) to die because of the August 2001 attack.
The US is seeking the extradition of a Jordanian woman convicted of murder by Israel for her involvement in the attack.
In 2003, an Israeli court sentenced Ahlam Tamimi to 16 life sentences.
She has Jordanian citizenship, but was born in the West Bank.
She was released in 2011 when Israel struck a deal with Hamas, the Palestinian extremist group in Gaza. Hamas held their soldier captive for over five years.
Tamimi helped Iz al-Din bomber Suheil al-Masri carry out the attack.
She settled in Jordan after her release and said she was proud of her involvement in the crime.
Tamimi is on the list of the most wanted terrorists of the US Federal Bureau of Investigation (FBI).
The US says it is seeking her extradition on charges of conspiracy to use weapons of mass destruction against Americans.
The parents of the then 15-year-old Malki Roth, one of the three Americans killed in the attack, have been campaigning for years for the US to do more to extradite Tamima.
The Sbarro restaurant was at a busy intersection in the center of Jerusalem.
It was packed with diners when Tamimi and Masri, both members of Hamas, entered the restaurant on August 9.
Tamimi pre-selected a target and left before Masri blew himself up.
15 people died and 130 were injured.
This suicide bombing by Hamas was one of many during the second Intifada – the Palestinian uprising against Israel, which began in 2000 and lasted for five years.